Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetone | HCID 6571 | — |
| Reactant | 3-Thiocarbamoyl-azetidine-1-carboxylic acid tert-butyl ester | HCID 57473379 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 67979293 | HCID 67979293 | — |
Reaction Steps
To 145 mg (0.67 mmol) 3-thiocarbamoyl-azetidine-1-carboxylic acid tert-butyl ester in 3 mL MeOH in a sealed tube was added 64 μL (0.8 mmol) chloroacetone, and the reaction was stirred at 90° C. for 3 hours. After evaporation of the solvent the product was purified by column chromatography (silica, heptane/EtOAc 8:2 to 6:4).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09346816B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-b2565e503a0d412481cfca4a53ede314 |
|---|
| Source note | uspto-grants-2016_05 |
|---|
