Trifluoroacetic acid → Trifluoroacetic acid

HRID 528754Notes

Reaction equation

HRID 528754 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([CH2:12][N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[CH2:9]1)=O)(C)(C)C.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]>C(Cl)Cl>[NH:8]1[CH2:11][CH:10]([CH2:12][N:13]2[CH:17]=[CH:16][CH:15]=[N:14]2)[CH2:9]1.[C:18]([OH:24])([C:20]([F:23])([F:22])[F:21])=[O:19]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 679792833-Pyrazol-1-ylmethyl-azetidine-1-carboxylic acid tert-butyl ester

Product 2

HCID 6422Trifluoroacetic acidHCID 674577591-(Azetidin-3-ylmethyl)-1H-pyrazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 41.5 mg (0.17 mmol) 3-pyrazol-1-ylmethyl-azetidine-1-carboxylic acid tert-butyl ester was added 2 mL of 25% TFA in DCM and the reaction was stirred at room temperature for 1 hour. The solvent was evaporated to give the desired product as a TFA salt, which was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-9172fa60505449c7abcc5589bf72bf03
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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