Trifluoroacetic acid → Trifluoroacetic acid

HRID 528759Notes

Reaction equation

HRID 528759 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9]1)=O)(C)(C)C.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>C(Cl)Cl>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[NH:8]1[CH2:11][CH:10]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:9]1.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67979307HCID 67979307, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67456895HCID 67456895, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 257 mg (1.04 mmol) 3-pyridin-2-ylmethyl-azetidine-1-carboxylic acid tert-butyl ester was added 2 mL DCM and 2 mL TFA. The mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the desired product as a TFA salt, which was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-9d699e1967da4a3fac550e231bf1956f
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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