Trifluoroacetic acid → Trifluoroacetic acid

HRID 528762Notes

Reaction equation

HRID 528762 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12](=[O:21])[C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)[CH2:9]1)=O)(C)(C)C.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]>C(Cl)Cl>[F:25][C:24]([F:27])([F:26])[C:22]([OH:28])=[O:23].[NH:8]1[CH2:11][CH:10]([C:12]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=2)=[O:21])[CH2:9]1.[C:22]([OH:28])([C:24]([F:27])([F:26])[F:25])=[O:23]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67979378HCID 67979378, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67458791HCID 67458791, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 714 mg (2.45 mmol) 3-(4-methoxy-benzoyl)-azetidine-1-carboxylic acid tert-butyl ester in 10 mL DCM was added 10 mL TFA and the mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the desired product as a TFA salt, which was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-302081d7d8d24be5b216b4f63936b464
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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