HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-Ethynyl-pyrrolidinium trifluoro-acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 3-ethynylpyrrolidine-1-carboxylate | HCID 54012212 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Ethynyl-pyrrolidinium trifluoro-acetate | HCID 86667176 | — |
Reaction Steps
To 0.85 g (4.35 mmol) 3-Ethynyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL DCM was added 2 mL (26.0 mmol) TFA and stirring was continued at room temperature for 3 h. The solvents were evaporated and the residue was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346816B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-c1eb13ada4284922a86903b907fe8526 |
| Source note | uspto-grants-2016_05 |