Trifluoroacetic acid → 3-Ethynyl-pyrrolidinium trifluoro-acetate

HRID 528776Notes

Reaction equation

HRID 528776 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH:10]([C:13]#[CH:14])[CH2:9]1)=O)(C)(C)C.[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([O-:21])=[O:16].[C:13]([CH:10]1[CH2:11][CH2:12][NH2+:8][CH2:9]1)#[CH:14]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54012212tert-Butyl 3-ethynylpyrrolidine-1-carboxylate

Product 1

HCID 866671763-Ethynyl-pyrrolidinium trifluoro-acetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 0.85 g (4.35 mmol) 3-Ethynyl-pyrrolidine-1-carboxylic acid tert-butyl ester in 30 mL DCM was added 2 mL (26.0 mmol) TFA and stirring was continued at room temperature for 3 h. The solvents were evaporated and the residue was used for the next step without further purification.

Workup

  1. customThe solvents were evaporated
  2. customthe residue was used for the next step without further purification

Sources & evidence

ORD record
ord-c1eb13ada4284922a86903b907fe8526
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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