HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4,4-Difluoro-perhydro-azepinium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl 4,4-difluoroazepane-1-carboxylate | HCID 58110242 | — |
| Product | 4,4-Difluoro-perhydro-azepinium chloride | HCID 67455628 | — |
Reaction Steps
To 830 mg (3.53 mmol) of 4,4-Difluoro-perhydro-azepine-1-carboxylic acid tert-butyl ester was added 5 mL of 2 M aq. HCl and stirring was continued overnight at room temperature. The reaction mixture was freeze dried and used for the next step without further purification
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346816B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-e2a839af5d554d9aadeda1c107cbe790 |
| Source note | uspto-grants-2016_05 |