Hydrochloric Acid → 4,4-Difluoro-perhydro-azepinium chloride

HRID 528780Notes

Reaction equation

HRID 528780 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][C:11]([F:16])([F:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:17]>>[Cl-:17].[F:15][C:11]1([F:16])[CH2:12][CH2:13][CH2:14][NH2+:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58110242Tert-butyl 4,4-difluoroazepane-1-carboxylate

Product 1

HCID 674556284,4-Difluoro-perhydro-azepinium chloride

Procedure

To 830 mg (3.53 mmol) of 4,4-Difluoro-perhydro-azepine-1-carboxylic acid tert-butyl ester was added 5 mL of 2 M aq. HCl and stirring was continued overnight at room temperature. The reaction mixture was freeze dried and used for the next step without further purification

Workup

  1. customdried
  2. customused for the next step without further purification

Sources & evidence

ORD record
ord-e2a839af5d554d9aadeda1c107cbe790
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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