HuagongsheHuagongshe Chemistry Print Report · For research reference only
(Phenylthio)acetic acid → 1-(2-(Phenylthio)acetyl)indoline-5-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (Phenylthio)acetic acid | HCID 59541 | — |
| Reactant | 2,3-dihydro-1H-indole-5-sulfonamide | HCID 8027252 | — |
| Reactant | 1-(2-(3,4-Dichlorophenyl)acetyl)indoline-5-sulfonamide | HCID 71061053 | — |
| Product | 1-(2-(Phenylthio)acetyl)indoline-5-sulfonamide | HCID 71060712 | 45% |
Reaction Steps
Following a procedure analogous to that for the synthesis of Intermediate 64, indoline-5-sulfonamide (Intermediate 54A, 120 mg, 0.60 mmol) and 2-(phenylthio)acetic acid (117 mg, 0.70 mmol) were converted to the title compound (100 mg, 45%). 1H NMR (DMSO-d6) δ 8.09 (d, J=8.4 Hz, 1H), 7.67-7.62 (m, 2H), 7.43-7.40 (m, 2H), 7.34-7.30 (m, 2H), 7.22-7.19 (m, 3H), 4.29 (t, J=8.6 Hz, 2H), 4.17 (s, 2H), 3.23 (t, J=8.5 Hz, 2H); MS(ESI+) m/z 348.9 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346795B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-eddafac2e563419bab44774925c1d4e0 |
| Source note | uspto-grants-2016_05 |