反应详情

Following a procedure analogous to that for the synthesis of Example 106, tert-butyl 3-formyl-3,4-dihydroisoquinoline-2(1H)-carboxylate (Molander, G. A. et al., Tetrahedron, 61:2631-2643 (2005)) (95 mg, 0.36 mmol) and 1-methylpiperazine (44 mg, 0.44 mmol) were converted to the title compound (110 mg, 88%), which was used in the subsequent step without purification. MS(ESI+) m/z 346.3 (M+H)+.