反应详情

Following a procedure analogous to that for the synthesis of Intermediate 1E, 4-chloro-N,N-dipropyl-5-(trifluoromethyl)-1H-pyrazol-3-amine (287 mg, 1.06 mmol) and 1-benzyl 3-ethyl 4-fluoroisophthalate (Intermediate 91B, 268 mg, 0.89 mmol) were converted to the title compound (231 mg, 47%). MS(ESI+) m/z 552.3 (M+H)+.