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1-Benzyl 3-ethyl 4-fluoroisophthalate → 1-Benzyl 3-ethyl 4-(4-chloro-3-(dipropylamino)-5-(trifluoromethyl)-1H-pyrazol-1-yl)isophthalate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Benzyl 3-ethyl 4-fluoroisophthalate | HCID 71060993 | — |
| 反応物 | 4-chloro-N,N-dipropyl-5-(trifluoromethyl)-1H-pyrazol-3-amine | HCID 71062226 | — |
| 生成物 | 1-Benzyl 3-ethyl 4-(4-chloro-3-(dipropylamino)-5-(trifluoromethyl)-1H-pyrazol-1-yl)isophthalate | HCID 71062240 | 47% |
反応手順
Following a procedure analogous to that for the synthesis of Intermediate 1E, 4-chloro-N,N-dipropyl-5-(trifluoromethyl)-1H-pyrazol-3-amine (287 mg, 1.06 mmol) and 1-benzyl 3-ethyl 4-fluoroisophthalate (Intermediate 91B, 268 mg, 0.89 mmol) were converted to the title compound (231 mg, 47%). MS(ESI+) m/z 552.3 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09346795B2 |
| 出典データセット | uspto-grants-2016_05 |
| ORD ID | ord-b4a69970f8ce41f3b93444760049d14f |
| 出典メモ | uspto-grants-2016_05 |