反应详情

Following a procedure analogous to that for the synthesis of Intermediate 223C, tert-butyl 4-formyl-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (59 mg, 0.16 mmol) and nitroethane (0.023 mL, 0.32 mmol) were converted to the title compound as a crude brown oil (1:1 mixture of diastereomers by LC-MS) which was used directly without further purification. MS(ESI+) m/z 441.3 (M+H)+.