Nitroethane → tert-Butyl 4-(1-hydroxy-2-nitropropyl)-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate

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Reaction Steps

Following a procedure analogous to that for the synthesis of Intermediate 223C, tert-butyl 4-formyl-3-(1,2,3,4-tetrahydroisoquinoline-2-carbonyl)benzoate (59 mg, 0.16 mmol) and nitroethane (0.023 mL, 0.32 mmol) were converted to the title compound as a crude brown oil (1:1 mixture of diastereomers by LC-MS) which was used directly without further purification. MS(ESI+) m/z 441.3 (M+H)+.

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