HRID529039

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CCCCN(CCCC)c1nccc(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)OC(C)(C)C)n1

HCID71060816

未命名化合物

PRODUCTS

生成物

结构：CCCCN(CCCC)c1nccc(-c2ccc(C(=O)NS(=O)(=O)c3ccc4ccccc4c3)cc2C(=O)O)n1

HCID71060720

未命名化合物

收率 95%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

To a solution of tert-butyl 2-(2-(dibutylamino)pyrimidin-4-yl)-5-(naphthalen-2-ylsulfonylcarbamoyl)benzoate (110 mg, 0.18 mmol) in DCM (2.0 mL) was added TFA (2.0 mL). The reaction mixture was stirred at room temperature for 3 h and concentrated in vacuo to give the title compound (95 mg, 95%), which was used in subsequent reaction without purification. MS(ESI+) m/z 561.2 (M+H)+.

WORKUP

后处理

concentrationconcentrated in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-dc3c205aacdf4b25a1af7ec0ff1f4d6d
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09346795B2
来源说明: uspto-grants-2016_05

反应 SMILES

[CH2:1]([N:5]([CH2:41][CH2:42][CH2:43][CH3:44])[C:6]1[N:11]=[C:10]([C:12]2[CH:24]=[CH:23][C:22]([C:25](=[O:40])[NH:26][S:27]([C:30]3[CH:39]=[CH:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=3)(=[O:29])=[O:28])=[CH:21][C:13]=2[C:14]([O:16]C(C)(C)C)=[O:15])[CH:9]=[CH:8][N:7]=1)[CH2:2][CH2:3][CH3:4].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([N:5]([CH2:41][CH2:42][CH2:43][CH3:44])[C:6]1[N:11]=[C:10]([C:12]2[CH:24]=[CH:23][C:22]([C:25](=[O:40])[NH:26][S:27]([C:30]3[CH:39]=[CH:38][C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=3)(=[O:28])=[O:29])=[CH:21][C:13]=2[C:14]([OH:16])=[O:15])[CH:9]=[CH:8][N:7]=1)[CH2:2][CH2:3][CH3:4]