Lithium hydroxide, monohydrate → HCID 178440099, compound

HRID 52914Notes

Reaction equation

HRID 52914 reaction equation
[OH:1][CH:2]([C:4]1[N:5]=[C:6]([CH2:32][CH2:33][CH3:34])[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:8]=1[C:9]([O:11]CC)=[O:10])[CH3:3].O.[OH-].[Li+]>>[OH:1][CH:2]([C:4]1[N:5]=[C:6]([CH2:32][CH2:33][CH3:34])[N:7]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]3[NH:31][N:30]=[N:29][N:28]=3)=[CH:17][CH:16]=2)[C:8]=1[C:9]([OH:11])=[O:10])[CH3:3]

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 178440096HCID 178440096, compound

Product 1

HCID 178440099HCID 178440099, compoundYield 64.9%

Procedure

Following a procedure similar to that described in Example 36, 0.82 g of ethyl 4-(1-hydroxyethyl)-2-propyl-1-{4-[2-(tetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in Example 40(c)] was hydrolyzed using 0.43 g of lithium hydroxide monohydrate, to give 0.50 g of the title compound as a powder, melting at 198°-201° C.

Sources & evidence

ORD record
ord-ddcc95029f59468d807cd246e4316a30
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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