Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 529208Notes

Reaction equation

HRID 529208 reaction equation
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

Product 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochlorideYield 95%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To the compound (0.50 g, 1.8 mmol) obtained in step 1 were added water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol). Acetonitrile (10 ml) was added to dissolve the mixture, and the solution was concentrated under reduced pressure, and lyophilized to give the title compound (0.54 g, 1.7 mmol, 95%).

Workup

  1. dissolutionto dissolve the mixture
  2. concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-9c7fe5a3e3b24d4d85ca86f0be782854
Source dataset
uspto-grants-2016_05
Patent number
US09346821B2

Reaction notes

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