Potassium Hydroxide → HCID 118194600, compound

HRID 529284Notes

Reaction equation

HRID 529284 reaction equation
[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:19][CH2:20][CH3:21])[C:10]([O:17][CH3:18])([O:15][CH3:16])[C:11]([O:13]C)=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[K+]>CO>[C:1]([O:5][C:6]([NH:8][C@@H:9]([CH2:19][CH2:20][CH3:21])[C:10]([O:15][CH3:16])([O:17][CH3:18])[C:11]([OH:13])=[O:12])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 118204328HCID 118204328, compound

Product 1

HCID 118194600HCID 118194600, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To ((S)-methyl 3-((tert-butoxycarbonyl)amino)-2,2-dimethoxyhexanoate) of Example 16 (0.8 mmol) in methanol (8 mL) was added an aqueous KOH solution (0.13 mL, 2.4 mmol, 50 w/w %) and the reaction was stirred for 20 h. pH was adjusted to pH=3 with 1N HCl and extraction with CH2Cl2 provided 260 mg of the crude acid.

Workup

  1. extractionwas adjusted to pH=3 with 1N HCl and extraction with CH2Cl2

Sources & evidence

ORD record
ord-e4ef72100cad456fab096fd4627debcd
Source dataset
uspto-grants-2016_05
Patent number
US09346853B2

Reaction notes

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