Benzylamine → HCID 118201132, compound

HRID 529291Notes

Reaction equation

HRID 529291 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:9]1([CH2:13][CH:14]=O)[CH2:12][CH2:11][CH2:10]1>C(Cl)Cl>[CH:9]1([CH2:13][CH:14]=[N:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22386168Cyclobutylacetaldehyde

Product 1

HCID 118201132HCID 118201132, compoundYield 105.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Benzylamine (2.95 g, 27.5 mmol) was added to a mixture of cyclobutylacetaldehyde (30.6 mmol) in CH2Cl2 (˜238 mL) and molecular sieves (5.0 g) and the mixture was stirred at room temperature for 5.5 hours. The mixture was filtered over Celite and the solvent was removed under vacuum to yield 5.45 g of crude N-(2-cyclobutylethylidene)-1-phenylmethanamine.

Workup

  1. filtrationThe mixture was filtered over Celite
  2. customthe solvent was removed under vacuum

Sources & evidence

ORD record
ord-68fd615743254ce5821775dd2ee41d1b
Source dataset
uspto-grants-2016_05
Patent number
US09346853B2

Reaction notes

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