HRID52940

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

2 次

结构：CCCCc1nc(C(O)(C(C)C)C(C)C)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID19036078

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nc(C(O)(C(C)C)C(C)C)c(C(N)=O)n1Cc1ccc(-c2ccccc2C(=O)O)cc1

HCID19036169

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Following a procedure similar to that described in Example 45(d), but using 220 mg of 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-[1-hydroxy-2-methyl-1-(1-methylethyl)propyl]imidazole-5-carboxamide [prepared as described in step (b) above] and 4.5 ml of a 4N solution of hydrogen chloride in dioxane, 201 mg of the hydrochloride of the title compound were obtained as an amorphous solid, melting at 178°-181° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-68dc826da99c4d1c99769019b82ab039
来源数据集: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05616599
来源说明: uspto-grants-1997_04

反应 SMILES

C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([NH2:28])=[O:27])=[C:24]([C:29]([OH:36])([CH:33]([CH3:35])[CH3:34])[CH:30]([CH3:32])[CH3:31])[N:23]=[C:22]2[CH2:37][CH2:38][CH2:39][CH3:40])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl>O1CCOCC1>[CH2:37]([C:22]1[N:21]([CH2:20][C:17]2[CH:16]=[CH:15][C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:6]([OH:7])=[O:5])=[CH:19][CH:18]=2)[C:25]([C:26]([NH2:28])=[O:27])=[C:24]([C:29]([OH:36])([CH:33]([CH3:34])[CH3:35])[CH:30]([CH3:32])[CH3:31])[N:23]=1)[CH2:38][CH2:39][CH3:40]