反应详情

To a round bottom flask was added (S)-methyl 3-(3-(tert-butoxycarbonylamino)-2-oxoazepan-1-yl)propanoate (15 mg, 0.048 mmol) and a solution of 4 N HCl (119 μL, 0.477 mmol) in dioxane. The reaction was stirred at rt for 3 hr. The reaction was concentrated and the residue was dried over vacuum pump for 5 hr to give (S)-methyl 3-(3-amino-2-oxoazepan-1-yl)propanoate (10 mg, 0.047 mmol, 98% yield) as a white semi-solid.

1. concentrationThe reaction was concentrated
2. customthe residue was dried over vacuum pump for 5 hr