Hydrochloric Acid → HCID 68292003, compound

HRID 529471Notes

Reaction equation

HRID 529471 reaction equation
[O:1]=[C:2]1[C@@H:7]([NH:8]C(=O)OC(C)(C)C)[CH2:6][CH2:5][CH2:4][N:3]1[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.Cl>O1CCOCC1>[NH2:8][C@H:7]1[CH2:6][CH2:5][CH2:4][N:3]([C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:2]1=[O:1]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 50940452HCID 50940452, compound

Product 1

HCID 68292003HCID 68292003, compoundYield 90.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a round bottom flask was added (S)-tert-butyl 2-oxo-1-phenylpiperidin-3-ylcarbamate (100 mg, 0.344 mmol) and 4 N HCl in dioxane (2.2 mL). The reaction was stirred at rt for 3 hr. The solvent was removed to give (S)-3-amino-1-phenylpiperidin-2-one (70 mg, 0.31 mmol, 90% yield) as an HCl salt. Anal. Calcd. for C11H14N2O m/z 190.2. found: 191.2 (M+H)+.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-c567c5aeae82413fae54861d45c55532
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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