反应详情

To a 2-neck round bottom flask was added (Z)-tert-butyl 4,4-dimethyl-2-oxo-1-phenyl-2,3,4,7-tetrahydro-1H-azepin-3-ylcarbamate (7 mg, 0.02 mmol), 10% Pd/C (2.3 mg, 0.021 mmol) and EtOAc (1 mL). The reaction was then charged with hydrogen with a balloon and then stirred at rt for 2 hr. The reaction was filtered through CELITE® and the filtrate was concentrated to give tert-butyl 4,4-dimethyl-2-oxo-1-phenylazepan-3-ylcarbamate (6.5 mg, 0.020 mmol, 92% yield) as a clear film. Anal. Calcd. for C19H28N2O3 m/z 332.2. found: 333.2 (M+H)+.

1. filtrationThe reaction was filtered through CELITE®
2. concentrationthe filtrate was concentrated