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HRID529488

反应详情

EQUATION

反应方程式

HRID 529488 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N[C@H]1CCS[C@H]2CCC[C@@H](C(=O)Nc3nccs3)N2C1=O
HCID86706202

未命名化合物

PRODUCTS

生成物

1
结构：Cl.N[C@H]1CCS[C@H]2CCC[C@@H](C(=O)Nc3nccs3)N2C1=O
HCID86706203

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To a round bottom flask was added tert-butyl (4S,7S,10aS)-5-oxo-7-(thiazol-2-ylcarbamoyl)octahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (35 mg, 0.082 mmol) and 4 M HCl in dioxane (1 mL). The mixture was stirred at rt for 1 h. The reaction mixture was concentrated to give (4S,7S,10aS)-4-amino-5-oxo-N-(thiazol-2-yl)octahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxamide hydrochloride salt (30 mg, 0.082 mmol, 100% yield).

WORKUP

后处理

  1. concentrationThe reaction mixture was concentrated