Hydrochloric Acid → HCID 19036198, compound

HRID 52949Notes

Reaction equation

C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([NH2:28])=[O:27])=[C:24]([CH:29]([OH:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[N:23]=[C:22]2[CH2:35][CH2:36][CH2:37][CH3:38])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl>>[CH2:35]([C:22]1[N:21]([CH2:20][C:17]2[CH:18]=[CH:19][C:14]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=3[C:6]([OH:7])=[O:5])=[CH:15][CH:16]=2)[C:25]([C:26]([NH2:28])=[O:27])=[C:24]([CH:29]([OH:34])[C:30]([CH3:32])([CH3:33])[CH3:31])[N:23]=1)[CH2:36][CH2:37][CH3:38]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19036256HCID 19036256, compound

Product 1

HCID 19036198HCID 19036198, compound

Procedure

Following a procedure similar to that described in Example 52(c), but using 326 mg of 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-2-butyl-4-(1-hydroxy-2,2-dimethylpropyl)imidazole-5-carboxamide [prepared as described in step (e) above], 228 mg of the hydrochloride of the title compound were obtained as a powdery solid, melting at 150°-154° C. (with softening).

Sources & evidence

ORD record: ord-be22e8c9a0f94bc58432a050dd8869c7
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616599

Reaction notes

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