反应详情

To a solution of (S)-tert-butyl 1-benzyl-2-oxoazepan-3-ylcarbamate (340 mg, 1.07 mmol) in DCM (5 mL) was added solution of 4 M HCl in dioxane (0.243 mL, 0.971 mmol) at rt under argon. The reaction was allowed to stir at rt for 5 hr. The reaction mixture was concentrated and dried under vacuum to give (S)-3-amino-1-benzylazepan-2-one hydrochloride (210 mg, 0.962 mmol, 99% yield) as a white solid. Anal. Calcd. for C13H18N2O m/z 218.3. found: 219.3 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. customdried under vacuum