3-Methoxybenzyl bromide → (S)-3-Amino-1-(3-methoxybenzyl)azepan-2-one

HRID 529504Notes

Reaction equation

HRID 529504 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:4]1=[O:17].BrCC1C=CC=[C:22]([O:26]C)C=1>>[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:26][CH3:22])[CH:12]=2)[C:4]1=[O:17]

Participants

3

Reactant 2

HCID 40672073-Methoxybenzyl bromideHCID 68292429(S)-3-amino-1-benzylazepan-2-one hydrochloride

Product 1

HCID 68292822(S)-3-Amino-1-(3-methoxybenzyl)azepan-2-one

Procedure

(S)-3-Amino-1-(3-methoxybenzyl)azepan-2-one (175 mg, 0.705 mmol) was synthesized as described for the preparation of Intermediate 42 using 1-(bromomethyl)-3-methoxybenzene in step A. Anal. Calcd. for C14H20N2O2 m/z 248.3. found: 249.3 (M+H)+.

Sources & evidence

ORD record
ord-5f4616aeac494468961effe6e31d77d5
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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