1-(Bromomethyl)-3-chlorobenzene → (S)-3-Amino-1-(3-chlorobenzyl)azepan-2-one hydrochloride

HRID 529513Notes

Reaction equation

HRID 529513 reaction equation
[ClH:1].[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:4]1=[O:17].BrCC1C=CC=C([Cl:26])C=1>>[ClH:26].[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([Cl:1])[CH:12]=2)[C:4]1=[O:17]

Participants

3

Reactant 2

HCID 698381-(Bromomethyl)-3-chlorobenzeneHCID 68292429(S)-3-amino-1-benzylazepan-2-one hydrochloride

Product 1

HCID 68292318(S)-3-Amino-1-(3-chlorobenzyl)azepan-2-one hydrochloride

Procedure

(S)-3-Amino-1-(3-chlorobenzyl)azepan-2-one hydrochloride (190 mg, 0.657 mmol) was synthesized as described for the preparation of Intermediate 42 using 1-(bromomethyl)-3-chlorobenzene in step A.

Sources & evidence

ORD record
ord-64148bddf62445fcbcbeb076fdc5a417
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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