反应详情

To a stirred solution of (S)-tert-butyl 1-(3-chlorophenyl)-2-oxoazepan-3-ylcarbamate (35 mg, 0.10 mmol) in DCM (2 mL) was added 4.0 M HCl in dioxane (0.258 mL, 1.03 mmol) at rt under argon. The reaction was stirred at rt for 6 hr. The reaction mixture was concentrated and dried under vacuum to give (S)-3-amino-1-(3-chlorophenyl)azepan-2-one hydrochloride (27 mg, 0.098 mmol, 95% yield) as white solid. Anal. Calcd. for C12H15ClN2O m/z 238.2. found: 239.1 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. customdried under vacuum