4-Chlorophenylboronic acid → (S)-3-Amino-1-(4-chlorophenyl)azepan-2-one hydrochloride

HRID 529517Notes

Reaction equation

HRID 529517 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[CH:11]=2)[C:4]1=[O:17].[Cl:18]C1C=CC(B(O)O)=CC=1>>[ClH:16].[NH2:2][C@H:3]1[CH2:9][CH2:8][CH2:7][CH2:6][N:5]([C:10]2[CH:15]=[CH:14][C:13]([Cl:18])=[CH:12][CH:11]=2)[C:4]1=[O:17]

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 68291572(S)-3-amino-1-(3-chlorophenyl)azepan-2-one hydrochloride

Product 1

HCID 68292068(S)-3-Amino-1-(4-chlorophenyl)azepan-2-one hydrochloride

Procedure

(S)-3-Amino-1-(4-chlorophenyl)azepan-2-one hydrochloride (35 mg, 0.127 mmol) was synthesized as described for the preparation of Intermediate 49 using 4-chlorophenylboronic acid in step A. Anal. Calcd. for C12H15ClN2O m/z 238.8. found: 239.2 (M+H)+.

Sources & evidence

ORD record
ord-edfda83a2ccd40babafe5ca6596d97b0
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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