反应详情

A solution of HCl (4.0 N in 1,4-dioxane, 2.33 mL, 9.32 mmol) was added to a 0° C. solution of tert-butyl (7S,10aR,Z)-6-oxo-1,2,3,4,6,7,8,10a-octahydropyrido[1,2-a]azepin-7-ylcarbamate (653 mg, 2.33 mmol) in 1,4-dioxane (0.93 mL). The reaction mixture was then stirred at rt for 1 hr. The reaction mixture was concentrated and dried under vacuum to give (7S,10aR,Z)-7-amino-1,2,3,4,7,8-hexahydropyrido[1,2-a]azepin-6(10aH)-one hydrochloride (504 mg, 2.33 mmol, 100% yield) as a tan solid. Anal. Calcd. for C10H16N2O m/z 180.2. found: 181.0 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. customdried under vacuum