(7S,10aR)-7-aminooctahydropyrido[1,2-a]azepin-6(7H)-one hydrochloride → (7S,11aS)-7-Aminooctahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrogen chloride

HRID 529530Notes

Reaction equation

HRID 529530 reaction equation
[ClH:1].N[C@@H]1C(=O)N2CCCC[C@@H]2CCC1.Cl.[NH2:16][C@@H:17]1[C:24](=[O:25])[N:23]2[CH2:26][CH2:27][CH2:28][CH2:29][C@@H:22]2[CH:21]=[CH:20][CH2:19][CH2:18]1>>[ClH:1].[NH2:16][C@@H:17]1[C:24](=[O:25])[N:23]2[CH2:26][CH2:27][CH2:28][CH2:29][C@@H:22]2[CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 86706215(7S,10aR)-7-aminooctahydropyrido[1,2-a]azepin-6(7H)-one hydrochlorideHCID 86706217(7S,11aR,Z)-7-Amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride

Product 1

HCID 86706219(7S,11aS)-7-Aminooctahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrogen chloride

Procedure

(7S,11aS)-7-Aminooctahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrogen chloride (273 mg, 1.17 mmol) was synthesized as described for the preparation of Intermediate 54 using (7S,11aR,Z)-7-amino-3,4,7,8,9,11a-hexahydro-1H-pyrido[1,2-a]azocin-6(2H)-one hydrochloride. Anal. Calcd. for C11H20N2O m/z 196.2. found: 197.0 (M+H)+.

Sources & evidence

ORD record
ord-8a23ae6ed71c4fb88dc91005ccc6f0d0
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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