(S,Z)-3-amino-1-phenyl-1,4,5,8-tetrahydroazocin-2(3H)-one → (S)-3-Amino-1-phenylazocan-2-one

HRID 529536Notes

Reaction equation

HRID 529536 reaction equation
Cl.N[C@@H]1C(=O)N2CCCC[C@@H]2CCC1.[NH2:15][C@H:16]1[CH2:23][CH2:22][CH:21]=[CH:20][CH2:19][N:18]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:17]1=[O:30]>>[NH2:15][C@H:16]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][N:18]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:17]1=[O:30]

Participants

3

Reactant 2

HCID 68292461(S,Z)-3-amino-1-phenyl-1,4,5,8-tetrahydroazocin-2(3H)-oneHCID 86706215(7S,10aR)-7-aminooctahydropyrido[1,2-a]azepin-6(7H)-one hydrochloride

Product 1

HCID 68292040(S)-3-Amino-1-phenylazocan-2-one

Procedure

(S)-3-Amino-1-phenylazocan-2-one (87 mg, 0.34 mmol) was synthesized as described for the preparation of Intermediate 54 using (S,Z)-3-amino-1-phenyl-1,4,5,8-tetrahydroazocin-2(3H)-one. Anal. Calcd. for C13H18N2O m/z 218.2. found: 219.0 (M+H)+.

Sources & evidence

ORD record
ord-0a26181ba7db448894c1da4409221678
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

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