反应详情

A solution of HCl (4.0 N in dioxane, 1 mL) was added to a reaction flask containing tert-butyl (4S,7S,10aS)-7-(methoxymethyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylcarbamate (83 mg, 0.24 mmol). The reaction mixture was then stirred at rt overnight. The reaction mixture was concentrated. Ether was added to the residue. A white solid formed. The mixture was stirred for 5 min and then filtered. The solid was dried under vacuum to give (4S,7S,10aS)-4-Amino-7-(methoxymethyl)hexahydro-2H-pyrido[2,1-b][1,3]thiazepin-5(7H)-one hydrochloride (63 mg, 0.22 mmol, 93% yield) as a white solid. Anal. Calcd. for C11H20N2O2S m/z 244.4. found: 245.1 (M+H)+.

1. concentrationThe reaction mixture was concentrated
2. additionEther was added to the residue
3. customA white solid formed
4. stirringThe mixture was stirred for 5 min
5. filtrationfiltered
6. customThe solid was dried under vacuum