N-Allylpyridin-3-amine → (S)-3-Amino-1-(pyridin-3-yl)azepan-2-one trifluoroacetate

HRID 529541Notes

Reaction equation

HRID 529541 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C@H:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([C:16]2[CH:21]=[CH:20][CH:19]=C[C:17]=2OC)[C:10]1=[O:24].C([NH:28]C1C=NC=CC=1)C=C>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:8][C@H:9]1[CH2:15][CH2:14][CH2:13][CH2:12][N:11]([C:16]2[CH:17]=[N:28][CH:19]=[CH:20][CH:21]=2)[C:10]1=[O:24]

Participants

3

Reactant 2

HCID 15366189N-Allylpyridin-3-amineHCID 68292209(S)-3-amino-1-(2-methoxyphenyl)azepan-2-one trifluoroacetate

Product 1

HCID 68292352(S)-3-Amino-1-(pyridin-3-yl)azepan-2-one trifluoroacetate

Procedure

(S)-3-Amino-1-(pyridin-3-yl)azepan-2-one trifluoroacetate (36 mg, 0.11 mmol) was synthesized as described for the preparation of Intermediate 62 using N-allylpyridin-3-amine in step A. Anal. Calcd. for C11H15N3O m/z 205.2. found: 206.1 (M+H)+.

Sources & evidence

ORD record
ord-664d4fa16ffd4c6994b4271ab4b9fd07
Source dataset
uspto-grants-2016_05
Patent number
US09346852B2

Reaction notes

Loading…