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HRID529603

反应详情

EQUATION

反应方程式

HRID 529603 的结构方程式

REACTANTS

反应物

2
结构：Cl.N[C@H]1CC=C[C@H]2CCCCN2C1=O
HCID68292606

未命名化合物

结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)O)Cc3ccccc3)C(=O)N21
HCID68311179

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC[C@@H]2SCC[C@H](NC(=O)[C@H](CC[C@H](Cc3ccccc3)C(=O)N[C@H]3CC=C[C@H]4CCCCN4C3=O)Cc3ccccc3)C(=O)N21
HCID68309860

未命名化合物

PROCEDURE

实验过程

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((7S,10aR,Z)-6-oxo-1,2,3,4,6,7,8,10a-octahydropyrido[1,2-a]azepin-7-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 53 (4.6 mg, 0.021 mmol) to give a white solid (12 mg, 90% yield). Anal. Calcd. for C41H52N4O6S m/z 728.4. found: 729.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.29-7.10 (11H, m), 7.05 (1H, d, J=7.1 Hz), 5.63-5.48 (2H, m), 5.39-5.30 (2H, m), 5.14-5.09 (1H, m), 5.04-4.96 (1H, m), 4.80-4.71 (1H, m), 4.02-3.93 (1H, m), 3.68 (3H, s), 3.21-3.10 (1H, m), 3.05-2.94 (1H, m), 2.87-2.69 (6H, m), 2.50-2.36 (3H, m), 2.31-2.18 (1H, m), 2.07-1.99 (2H, m), 1.89-1.45 (15H, m).