(7S,10aR,Z)-7-amino-1,2,3,4,7,8-hexahydropyrido[1,2-a]azepin-6(10aH)-one hydrochloride → (4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((7S,10aR,Z)-6-oxo-1,2,3,4,6,7,8,10a-octahydropyrido[1,2-a]azepin-7-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate

Participants

Reaction Steps

(4S,7S,10aS)-Methyl 4-((2R,5R)-2,5-dibenzyl-6-oxo-6-((7S,10aR,Z)-6-oxo-1,2,3,4,6,7,8,10a-octahydropyrido[1,2-a]azepin-7-ylamino)hexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate was synthesized as described in General Procedure H using Intermediate 23 (11 mg, 0.019 mmol) and Intermediate 53 (4.6 mg, 0.021 mmol) to give a white solid (12 mg, 90% yield). Anal. Calcd. for C41H52N4O6S m/z 728.4. found: 729.3 (M+H)+; 1H NMR (400 MHz, CDCl3) δ ppm 7.29-7.10 (11H, m), 7.05 (1H, d, J=7.1 Hz), 5.63-5.48 (2H, m), 5.39-5.30 (2H, m), 5.14-5.09 (1H, m), 5.04-4.96 (1H, m), 4.80-4.71 (1H, m), 4.02-3.93 (1H, m), 3.68 (3H, s), 3.21-3.10 (1H, m), 3.05-2.94 (1H, m), 2.87-2.69 (6H, m), 2.50-2.36 (3H, m), 2.31-2.18 (1H, m), 2.07-1.99 (2H, m), 1.89-1.45 (15H, m).

Provenance & Evidence