化工社化工社 化学情報印刷レポート · 研究参考用
4'-(Bromomethyl)-2-cyanobiphenyl → Ethyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4'-(Bromomethyl)-2-cyanobiphenyl | HCID 1501912 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 反応物 | HCID 178440079 | HCID 178440079 | — |
| 生成物 | Ethyl 1-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-4-(1-hydroxy-1-methylethyl)-2-propyl-1H-imidazole-5-carboxylate | HCID 15461993 | 95.3% |
反応手順
Following a procedure similar to that as described in Example 68(a), but using 4.01 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 5.0 g of 4'-bromomethylbiphenyl-2-carbonitrile and 1.97 g of potassium t-butoxide, 6.86 g of the title compound were obtained as crystals, melting at 92°-93° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05616599 |
| 出典データセット | uspto-grants-1997_04 |
| ORD ID | ord-07f739605b9f4176b0bb2cdb46997847 |
| 出典メモ | uspto-grants-1997_04 |