反应详情

温度

110 °C

To a degassed mixture of 2-chloro-5-(1-methyl-1H-pyrazol-4-yl)-4-((tetrahydro-2H-pyran-4-yl)oxy)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine (1 equiv), 4-amino-N,N,3-trimethylbenzamide (1 equiv) and cesium carbonate (3 equiv) in 1.4-dioxane (0.086 M) were added palladium acetate (0.3 equiv) and 2,2′-bis-diphenylphosphanyl-[1,1′]binaphthalenyl (0.6 equiv). The mixture was stirred at 110° C. for 2 h. The reaction was cooled to room temperature and filtered. The filtrate was concentrated and the residue obtained was purified by preparative thin layer chromatography (3.3% methanol in DCM) to afford the title compound (76% yield). MS (ESI) m/z 606.1 [M+1]+.

1. temperatureThe reaction was cooled to room temperature
2. filtrationfiltered
3. concentrationThe filtrate was concentrated
4. customthe residue obtained
5. customwas purified by preparative thin layer chromatography (3.3% methanol in DCM)