反应详情

A Grignard reagent was prepared from 56.7 g of 1-bromo-2,4,6-triisopropylbenzene and poured to 300 g of dry ice, whereupon dry ice sublimated. Hydrochloric acid was added to the reaction mixture for quenching, followed by extraction with 200 g of toluene. The organic layer was taken out, washed with water, and combined with 10 wt % sodium hydroxide aqueous solution. The aqueous layer was taken out, combined with 50 g of 35 wt % hydrochloric acid, and extracted with 200 g of toluene. The organic layer was washed with water again, and concentrated under reduced pressure. The concentrate was crystallized from 150 g of hexane. The crystal precipitate was filtered and dried, obtaining the target compound, 2,4,6-triisopropylbenzoic acid. Amount 39.7 g, yield 80%.

1. customfor quenching
2. extractionfollowed by extraction with 200 g of toluene
3. washwashed with water
4. extractionextracted with 200 g of toluene
5. washThe organic layer was washed with water again
6. concentrationconcentrated under reduced pressure
7. customThe concentrate was crystallized from 150 g of hexane
8. filtrationThe crystal precipitate was filtered
9. customdried