反应详情

A 1-L eggplant shaped flask was charged with 39.7 g of 2,4,6-triisopropylbenzoic acid (prepared in Synthesis Example 1-1), 13.4 g of sodium hydrogencarbonate, 160 g of methyl isobutyl ketone, and 40 g of water, which were stirred at room temperature for 24 hours. At the end of stirring, the reaction solution was concentrated, followed by twice of azeotropic dehydration with 100 g of methyl isobutyl ketone. To the solid precipitate, 300 g of diisopropyl ether was added, whereupon solid-liquid washing was conducted for 30 minutes. The solid was filtered and dried, obtaining the target compound, sodium 2,4,6-triisopropylbenzoate as white crystal. Amount 30.7 g, yield 80%.

1. stirringAt the end of stirring
2. concentrationthe reaction solution was concentrated
3. additionTo the solid precipitate, 300 g of diisopropyl ether was added, whereupon solid-liquid
4. washwashing
5. waitwas conducted for 30 minutes
6. filtrationThe solid was filtered
7. customdried