反应详情

A Grignard reagent was prepared from 28.4 g of 2-bromo-1,3,5-tricyclohexylbenzene (prepared in Synthesis Example 1-4) and poured to 300 g of dry ice, whereupon dry ice sublimated. Hydrochloric acid was added to the reaction mixture for quenching, followed by extraction with 200 g of isopropyl ether. The organic layer was taken out, washed with water, and combined with 150 g of 10 wt % sodium hydroxide aqueous solution. The aqueous layer was taken out, combined with 100 g of 35 wt % hydrochloric acid, and extracted with 200 g of diisopropyl ether. The organic layer was washed with water again, and concentrated under reduced pressure. The concentrate was crystallized from 150 g of hexane. The crystal precipitate was filtered and dried, obtaining the target compound, 2,4,6-tricyclohexylbenzoic acid. Amount 39.7 g, yield 80%.

1. customfor quenching
2. extractionfollowed by extraction with 200 g of isopropyl ether
3. washwashed with water
4. extractionextracted with 200 g of diisopropyl ether
5. washThe organic layer was washed with water again
6. concentrationconcentrated under reduced pressure
7. customThe concentrate was crystallized from 150 g of hexane
8. filtrationThe crystal precipitate was filtered
9. customdried