反应详情

温度

40 °C

The commercially available 2-tert-butyl-malonic acid diethyl ester (1 g, 4.6 mmol) is dissolved in EtOH (7 mL). A 1N NaOH solution (5.06 mL, 5.06 mmol) is added and the resulting mixture is stirred at 40° C. overnight. Next, the mixture is acidified to pH=1 with HCl. Extraction with EtOAc gives an organic phase that is dried over MgSO4, filtered and evaporated to give the desired product.

1. extractionExtraction with EtOAc
2. customgives an organic phase that
3. dry with materialis dried over MgSO4
4. filtrationfiltered
5. customevaporated