Potassium Carbonate → HCID 117858047, compound

HRID 529973Notes

Reaction equation

HRID 529973 reaction equation
C([O:4][C:5]1[CH:29]=[CH:28][CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[S:22][C:13]2[C:14]([CH3:21])([CH3:20])[O:15][C:16]([CH3:19])([CH3:18])[CH2:17][C:12]=2[C:11]=1[C:23]([NH2:25])=[O:24])=[O:8])(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.O1CCOCC1>[OH:4][C:5]1[CH:29]=[CH:28][CH:27]=[CH:26][C:6]=1[C:7]([NH:9][C:10]1[S:22][C:13]2[C:14]([CH3:21])([CH3:20])[O:15][C:16]([CH3:18])([CH3:19])[CH2:17][C:12]=2[C:11]=1[C:23]([NH2:25])=[O:24])=[O:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 117857904HCID 117857904, compound

Product 1

HCID 117858047HCID 117858047, compound

Reagents, catalysts & solvents 1

HCID 21966525Dioxane MethanolSolvent

Procedure

To a solution of 2-(2-acetoxybenzamido)-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide (200 mg, 0.48 mmol) in 4 mL of MeOH/dioxane=1:1, cooled to 0° C., is added potassium carbonate (66 mg, 0.52 mmol). The reaction mixture is stirred at room temperature for 90 min, filtered off and filtrate is then acidified with 1M HCl. A precipitate is formed which is separated by filtration to afford the desired compound which is used as such.

Workup

  1. filtrationfiltered off
  2. customA precipitate is formed which
  3. customis separated by filtration

Sources & evidence

ORD record
ord-61b146ec4e25412ab13bbbbe872f6ea7
Source dataset
uspto-grants-2016_05
Patent number
US09351955B2

Reaction notes

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