HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxyphthalimide → 2-(cyclopropylmethoxy)-1H-isoindole-1,3(2H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxyphthalimide | HCID 10665 | — |
| Reactant | Cyclopropanemethanol | HCID 75644 | — |
| Product | 2-(cyclopropylmethoxy)-1H-isoindole-1,3(2H)-dione | HCID 1484310 | 87% |
Reaction Steps
N-Hydroxyphthalimide and cyclopropyl-methanol were reacted as described for compound LIX in Example 27, to afford LXXXVI in 87% yield. 400 MHz 1H NMR (DMSO-d6, ppm) 7.86 (4H, s), 3.97 (2H, d, J=7.4 Hz), 1.22-1.11 (1H, m), 0.61-0.48 (2H, m), 0.34-0.22 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09351972B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-8b471e50c8d84325a94467e873c8ee7d |
| Source note | uspto-grants-2016_05 |