HRID530072

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10665

1H-Isoindole-1,3(2H)-dione, 2-hydroxy-

C8H5NO3

HCID75644

Cyclopropylmethanol

C4H8O

PRODUCTS

生成物

HCID1484310

2-(Cyclopropylmethoxy)-1H-isoindole-1,3(2H)-dione

C12H11NO3

收率 87%

PROCEDURE

实验过程

N-Hydroxyphthalimide and cyclopropyl-methanol were reacted as described for compound LIX in Example 27, to afford LXXXVI in 87% yield. 400 MHz 1H NMR (DMSO-d6, ppm) 7.86 (4H, s), 3.97 (2H, d, J=7.4 Hz), 1.22-1.11 (1H, m), 0.61-0.48 (2H, m), 0.34-0.22 (2H, m).

WORKUP

后处理

customto afford LXXXVI in 87% yield