Hydrochloric Acid → HCID 19036129, compound

HRID 53014Notes

Reaction equation

C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:35])([CH3:34])[CH3:33])=[O:27])=[C:24]([C:37]([OH:40])([CH3:39])[CH3:38])[N:23]=[C:22]2[CH2:41][O:42][CH2:43][CH3:44])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl>>[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][O:30][C:31](=[O:36])[C:32]([CH3:33])([CH3:34])[CH3:35])=[O:27])=[C:24]([C:37]([OH:40])([CH3:38])[CH3:39])[N:23]=[C:22]2[CH2:41][O:42][CH2:43][CH3:44])=[CH:16][CH:15]=1)([OH:7])=[O:5]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19036196HCID 19036196, compound

Product 1

HCID 19036129HCID 19036129, compound

Procedure

Following a procedure similar to that described in Example 96(b) but using 396 mg of pivaloyloxymethyl 1-{4-[2-(t-butoxycarbonyl)phenyl]phenyl}methyl-2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate [prepared as described in step (a) above], 312 mg of the hydrochloride of the title compound were obtained as an amorphous powder, melting at 65° C. (with softening).

Sources & evidence

ORD record: ord-6d0934589281464b938299515ccb55c6
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616599

Reaction notes

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