反应详情

Mix 8.2 g (0.02 mol) of (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium iodide (formula VI) with 15 ml (content greater than 40% by mass) hydrobromic acid, heat and reflux the mixture for 10 hours. Let it cool to room temperature, and add 120 ml of acetone. A pale yellow solid is produced. Filter and dry it to receive 6.4 g pale yellow solid with a yield of 80%.

1. temperatureheat
2. temperaturereflux the mixture for 10 hours
3. customA pale yellow solid is produced
4. filtrationFilter
5. customdry it