Methyl iodide → HCID 86712421, compound

HRID 530204Notes

Reaction equation

HRID 530204 reaction equation
[CH3:1][N:2]([C@H:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:13])[C@H:3]([C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1)[CH3:4].[CH3:20][I:21]>C(OCC)(=O)C>[I-:21].[OH:11][C:7]1[CH:6]=[C:5]([C@@H:3]([N+:2]([CH3:20])([CH3:1])[C@H:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])[CH3:4])[CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 426049503-((S)-1-(Methyl((S)-1-phenylethyl)amino)ethyl)phenol

Product 1

HCID 86712421HCID 86712421, compoundYield 88.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
60 °C

Procedure

Mix 5.1 g (0.02 mol) of 3-[(S)-1-(methyl-[(5)-1-phenylethyl]amino)ethyl]phenol (formula V) with 20 ml of ethyl acetate and 11.3 g (0.08 mol) of methyl iodide at room temperature, and heat the mixture to 60° C. for 10 hours. After cooling it to room temperature, filter and dry it to obtain 7.0 g yellow solid with a yield of 88%.

Workup

  1. temperatureAfter cooling it to room temperature
  2. filtrationfilter
  3. customdry it

Sources & evidence

ORD record
ord-b14e44889515444faf85fa31b5ab07ae
Source dataset
uspto-grants-2016_05
Patent number
US09353049B2

Reaction notes

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