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HRID530206

反应详情

EQUATION

反应方程式

HRID 530206 的结构方程式

REACTANTS

反应物

4
结构：CC#N
HCID6342

Acetonitrile

C2H3N

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCN(C)C(=O)Cl
HCID11240471

N-Ethyl-N-methylcarbamoyl chloride

C4H8ClNO

结构：C[C@@H](c1ccccc1)[N+](C)(C)[C@@H](C)c1cccc(O)c1.[I-]
HCID86712421

未命名化合物

2 次

PRODUCTS

生成物

1
结构：CCN(C)C(=O)Oc1cccc([C@H](C)[N+](C)(C)[C@@H](C)c2ccccc2)c1.[I-]
HCID86712425

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：OCCO
溶剂HCID174

Ethylene glycol

C2H6O2

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

Mix 7.9 g (0.02 mol) (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N—((S)-1-phenylethyl)ethanaminium iodide (formula VIII) with 180 ml of acetonitrile, 4.1 g (0.03 mol) of potassium carbonate, 3.6 g (0.03 mol) ethyl(methyl)carbamic chloride and 0.1 g of macrogol 400 at room temperature, heat the mixture to 60° C. and let it react for 12 hours. After cooling to room temperature, filter it and reduce the pressure to recover the solvent and receive 10.3 g of red-brown liquid to be directly used in the next reaction.

WORKUP

后处理

  1. customreact for 12 hours
  2. temperatureAfter cooling to room temperature
  3. filtrationfilter it
  4. customto recover the solvent
  5. customto be directly used in the next reaction